Ongoing regulatory changes, legal complexities, and operational challenges, make managing a compliant 340B program more demanding than ever. The 340B Program Handbook, 2nd Edition is a must-have resource for those seeking clear, actionable strategies to integrate 340B into the health-system pharmacy supply chain. It provides the essential tools and knowledge to help covered entities stay compliant, operate efficiently, and maximize the benefits of this critical federal program. Inside You’ll Find: Fully updated content reflects the latest developments, trends, and policy shifts in the 340B landscape. Step-by-step guidance in each chapter outlines key actions and best practices for implementation, oversight, and improvement. Compliance-focused insights help organizations navigate complex requirements and avoid common pitfalls, including a new chapter on avoiding duplicate discounts through clearinghouses. Self-assessment tools allow readers to evaluate their current 340B program’s strengths and areas for improvement.  Designed for real-world application, this book supports operational success, program integrity, and alignment with the 340B mission to serve more patients, more effectively. Whether you’re developing a new 340B program or refining an existing one, this handbook is a comprehensive resource to support ongoing success in a shifting healthcare environment.